ANNONASENSE (cherimoya extract) 10 g

ANNONASENSE AS A COMPONENT FOR COMBATING INFLAMMATORY PROCESSES

Annonasense is a unique active ingredient from the German company CLR, which won the gold medal among innovative cosmetic assets 2019 at In-cosmetics. AnnonaSense is recommended to eliminate discomfort and negative sensations characteristic of dry, sensitive and itchy skin. The active supports the homeostasis (balance) of the skin, reduces hypersensitivity and itching, improves the appearance of sensitive skin, supports the endocannabinoid system by activating the CB2 receptor. Through this action, it reduces inflammation caused by TRPV1.

Characteristics of the component and specifics of use

INCI: Annona Cherimola Fruit Extract Manufacturer's preservative: Sodium Dehydroacetate, Phenylpropanol

Dosage (percentage of input into cosmetics): 3 %. Do not use undiluted on the skin.

Solubility: in water at a temperature up to 45 C

Usage: dissolve in water, keep the pH of the finished product > 5.2.

Certification: COSMOS approved, NATRUE-certified. Halal-certified.

Storage: long-term storage is recommended in a dark place at a temperature of 10-25 °C, protect from direct sunlight and overheating.

Cherimoya extract as an alternative to cannabinoids

AnnonaSense is an extract of the unique plant Cherimoya (Annona cherimola), an edible fruit originating from South America. Before extraction, the cherimoya fruit is processed and dried, then it is crushed, fractionated and dried. After this procedure, the finished powder is gently extracted with aqueous buffer. The final product is obtained by subsequent filtration. CLR has developed a manufacturing process to obtain a cosmetic component containing, among other things, proteins and cyclopeptides in a single aqueous solution of the actives.

Cosmetic properties

AnnonaSense empowers the skin to establish a sustainable homeostatic balance, improving skin health and well-being. The powerful adaptogenic action of AnnonaSense supports the skin's endocannabinoid system by activating the CB2 receptor. Through this action, it reduces inflammation caused by TRPV1. AnnonaSense makes the skin less sensitive and more balanced, even itching is visibly reduced. The appearance of the skin is improved and the perception of well-being and quality of life is enhanced. Now let's talk more about receptors to understand the mechanism of action of the active ingredient.

Our skin is an "EBC/EX" balance system

EVS: The endogenous vanilloid system is the predominant system that controls inflammatory processes in the skin. The main vaniloid receptor is TRPV1 (transient receptor potential vaniloid). As a result of vaniloid receptor activation we feel irritation, burning, itching. A clear example of an activator is red pepper extract, which causes skin warming and burning.

ECS: The endocannabinoid system, the only system that can effectively and sustainably override the EBC. The endocannabinoid system is a key homeostatic regulator in the body, affecting almost every physiological system in the body. Activators of the CB1 and CB2 cannabinoid receptors include THC (D9-tetrahydrocannabinol found in marijuana), cannabidiols, and other non-psychotropic plant extracts (here meaning cherimoya extract).

And the main task of AnnonaSense component is to maintain the system of homeostasis (self-regulation) between these two systems of the organism by stabilising physiological processes in the skin. That is, when the skin is irritated, the EBC is switched on and we get the result on our face, and when using AnnonaSense - the balance is restored, the skin is soothed and we get back the feeling of comfort on the skin.

Main action in natural cosmetics

• Adaptogenic activity on the skin and balance of the EBC/EX systems
• Maintains the homeostasis (balance) of the skin
• Activates CB2 receptor
• Reduces the production of key mediators of inflammatory responses: CGRP, IL-1β, IL-8 and IL-6
• Reduces IL-31RA expression
• Reduces skin hypersensitivity and itching
• Improves skin appearance I
• mproves health and quality of life.

For which prescriptions it is recommended to buy AnnonaSense 

• Products for problematic and itch-prone skin
• "Anti-stress cosmetics to fight inflammatory processes in the skin
• Cosmetics for sensitive skin, including anti-cuperose products
• Cosmetic prevention of allergic dermatitis
• Cosmetic prophylaxis of atopic dermatitis
• Antihistamine cosmetics (cosmeceuticals, professional cosmetics)
• After-sun products

In-vivo study results: effects on skin sensitivity and irritation as well as on general well-being.

In view of the increasing expectations and health concerns of consumers, cosmetics manufacturers are asking themselves:

1.Can an active ingredient contribute to a noticeable reduction in skin sensitivity?

2.Can itching sensations be reduced better than placebo? Note: placebo effects can lead to a 40% reduction in itching.

3.Can the active ingredient support healthy skin?

4. What is the long-term impact on skin health and quality of life when using a simple water-soluble gel with an active ingredient?

To answer these questions, CLR conducted a series of in-vivo studies involving a group of people with conditions such as atopy, type IV allergies, psoriasis, and type II diabetes who experience regular skin discomfort (e.g. itching). They were men and women aged 18 - 70 years.

Biodegradability and hazards Not toxic and its ingredients are readily degraded by microorganisms. Does not pose a risk of water pollution.