X50 MYOCEPT 5 g

X50 Myocept Peptide Myorelaxant Solution

X50 Myocept is a peptide myorelaxant that works by blocking muscle movement to reduce the depth of mimic wrinkles. It consists of two peptides that work in synergy to reduce wrinkles by up to 20%. The ingredient's high efficacy is based on the unique "Cosmetic Drone" delivery system developed and patented by the Spanish company Infinitec. A small percentage of input in cosmetic products provides a low cost of the finished product, because for a cream of 50 ml you need only 0.5 ml of peptide X50 Myocept.

Characteristics of the ingredient and features of use

INCI: Water, Xanthan Gum, Palmitoyl Hexapeptide-52, Glycolic Acid, Lactic Acid, Palmitoyl Hexapeptide-18.

Manufacturer's peptide preservative system: Phenoxyethanol, Caprylyl Glycol, Glycerin, Glyceryl Caprylate, Phenylpropanol.

Dosage (percentage of use in cosmetics): 1 %. Do not apply undiluted to the skin.

Solubility: in water at temperature up to 45 C

Use: dissolve in water, introduce into the active phase of the cream or directly into the finished warm emulsion. It is necessary to maintain pH between 4.7 and 7.5 in the cosmetic product. 

Storage: it is recommended to store in a dark, cool place, away from direct sunlight and overheating. In summer it is better to store the peptide in the refrigerator.

How it works against expression wrinkles

The target of the X50 Myocept peptide complex is the skin's neurons and its main function is to reduce expression wrinkles. This peptide does not affect the wrinkles of aging because it does not interact with fibroblasts and does not stimulate collagen synthesis. It is most effective in the areas of expression wrinkles:

• Hound's feet and the area around the eyes
• Horizontal and vertical forehead wrinkles
• Nasolabial wrinkles
• Mouth lines, wrinkles.

 
How X50 Myocept works

X50 Myocept reduces calcium Ca+2 entry into neurons and blocks the formation of the SNARE protein complex: minimizing neuronal exocytosis. And its liposomal delivery system 

The maximum efficacy of the peptide at the lowest concentration of active ingredient compared to other myorelaxants is achieved thanks to its special liposomal form. It penetrates the dermis quickly but is released over a long period of time, acting selectively on the skin's nerve cells without affecting other cells.

Peptide Effectiveness: How to Get Rid of Wrinkles

In vitro test

30 women aged 40 to 55 years used a cream containing 1% encapsulated peptide X50 Myocept twice a day for 4 weeks. Area of application: around the eyes. The result showed an average wrinkle reduction of 20%. The maximum effective result was a 27% reduction in wrinkles.

Cosmetic Drone Delivery System

Cosmetic Drones have the following composition: polymer particles + active ingredient + ligand, i.e. it is a liposomal capsule with a special component called "ligand". In the graph below, you can see a comparison of the efficacy of conventional encapsulated actives and the capsule with ligand. As a result, cosmetic drones show 80% better results. 

This efficacy is based on the following principles

• Protection of the active inside the capsule and ensuring its stability in the formulation
• Delivering the active directly to the target site
• Improved penetration into the skin without compromising its barrier function
• Protect the active ingredient from degradation by skin proteases, thereby ensuring a longer lasting effect.

The basis of Cosmetic Drone is a structural particle capsule X50, the size of which varies between 175-300 nm. 

А. Active substance of choice

В. PLGA inner layer, where PLGA is a copolymer of PGA and PLA. FDA approved for use in pharmaceutical applications

С. Outer layer (PVA). Polyvinyl alcohol serves as an emulsifier for PLGA and influences the pharmaceutical properties of the capsules.

D. Hydrophilic linear chain. Linker used to avoid non-specific reactions at the membrane level and improve cellular selectivity. It bypasses the steric barrier (prevents undesirable side effects).

Е. Receptor peptide, specific for the receptor of the target cell.

This is how the system of the capsule itself is organized. However, in order for the drone to perform a specific mission, the final design requires a chemical bond between the specific ligand and the X50 capsule. It is the external ligand that dictates the mission and guides the specific X50 capsule to its destination.

As shown, the X50 Myocept peptide that targets the skin neuron uses a unique ligand that binds to the desired receptor. The ligand also acts as the drug when it interacts with the specific receptor. Once bound, the drone enters the target cell by endocytosis and the active ingredient is distributed and released gradually over a period of time.

Handmade Cosmetics Recipes and Reviews

If you are new to cream making - it is very difficult to make your right recipe. And in this we are ready to help you. Go to youtube channel Cosmetic Kitchen Beurre, where we have already developed many recipes for handmade cosmetics and share the technology of making cosmetics with your own hands. And also go to Blog by Beurre, where we share useful information about creating the right natural cosmetics.